Tamoximed (Tamoxifen Citrate) by Balkan Pharmaceuticals competes over the estrogen receptors in target cells, this way making estrogen ineffective. This action reduces estrogen sensitive tumours in women, and breast, or other feminine tissues (gynecomastia), in men.
Tamoximed is a non-steroidal compound which competitively inhibits estrogen receptors in its target organs (and/or estrogen-sensitive tumors); when present in cell nuclei, Tamoxifen Citrate-receptor-co-factor complexes prevent hypertrophy (overgrowth) of estrogen-sensitive cells.
Once in the body, Tamoximed is broken down into compounds that bind estrogen receptors without activating them: estrogen activity is blocked (reduced negative feedback inhibition) in pituitary and hypothalamus, allowing this drug to increase follicle-stimulating hormone and luteinizing hormone in the male body.
Tamoximed Effect on Bodybuilding
It didn’t take long before Nolvadex (Tamoximed) built a following in the bodybuilding scene soon after and became known as a top choice when it comes to getting a post cycle therapy or PCT going. This SERM can be used by men and women.
Developed by ICI – currently AstraZeneca – in 1961, Nolvadex, or Tamoxifen Citrate as it’s generically known, is formulated as a SERM that functions as an anti-estrogen and estrogen agonist at the same time.
Apart from having the ability to bind to the estradiol receptors to prevent estrogen hormones from being produced and performing their function in the body, Tamoximed also supports the overall health of the liver by helping regulate cholesterol at ideal levels. This simply means that when used for bodybuilding, this SERM isn’t just going to stave off the nasty side effects of having too much estrogen in the body like gynecomastia or “bitch tits,” sailing blood pressure levels and increased water retention, but also keep your liver in tiptop shape while at it.
Moreover, Tamoximed is also capable of inhibiting negative estrogenic feedback to the pituitary gland and hypothalamus, which promotes the release of higher amounts of follicle stimulating hormone (FSH) and luteinizing hormone (LH) that are crucial in the body’s natural production of testosterone.
How To Use Tamoximed
For on-cycle estrogen protection: The recommended dose for Tamoximed as an on-cycle estrogen protection agent is 10 to 20mg per day. However, it is also advised that the intake of carbohydrates and water should be closely monitored to achieve the best results.
For post cycle therapy (PCT): A standard dose of Tamoximed for PCT is 40mg daily for a couple of weeks. After that time, the dose should be halved to 20mg per day for the next 2 weeks. You should close this cycle with a 10mg daily dose for another week for the best results.
Tamoximed isn’t recommended for women who are pregnant or looking to get pregnant soon because of its ability to cut back estrogen count. Besides possibly having an effect on the overall development of the fetus, it can also decrease fertility.