Nolvaxyl (Tamoxifen) by Kalpa Pharmaceuticals is an antagonist of the estrogen receptor in breast tissue via its active metabolite, hydroxytamoxifen. In other tissues such as the endometrium, it behaves as an agonist, hence tamoxifen may be characterized as a mixed agonist/antagonist. It has been the standard endocrine (anti-estrogen) therapy for hormone receptor-positive early breast cancer in pre-menopausal women, although aromatase inhibitors have been proposed. Some breast cancer cells require estrogen to grow. Estrogen binds to and activates the estrogen receptor in these cells. Nolvaxyl is metabolized into compounds that also bind to the estrogen receptor but do not activate it.
Nolvaxyl PCT Bodybuilding
Nolvaxyl is very popular for preventing estrogen related gynecomastia, resulting from elevated estrogenic levels and is one of the most popular and utilized drug by athletes and bodybuilders worldwide, especially in the post cycle therapy. While using it the Nolvaxyl molecule bound to this receptor, estrogen is blocked from exerting any action, and the anti-estrogenic effect is achieved. Users should know that Nolvaxyl acts only as an estrogen antagonist and does not prevent aromatization process. Tamoxifen compounds proved the ability to increase production of follicle stimulating hormone and luteinizing hormone in the human body. It is accomplished by blocking the negative feedback inhibition caused by estrogen at the hypothalamus and pituitary gland.
The disadvantage of this steroid is in the fact that after its use discontinuation one can experience a rebound effect of the estrogen levels. Nolvaxyl can be stacked with such drugs as Mesterolone for a stronger anti-estrogenic effect. The combination of Tamoxifen Citrate, Clenbuterol Hydrochloride and Methandienone is also quite utilized by bodybuilders during a cycle. Patients taking Anastrozole or Letrozole should not take Nolvaxyl as serious effects of this interaction could occur.
How To Use Nolvaxyl PCT
The use of Nolvaxyl as an anti-oestrogen is usually only advised if necessary. Oestrogen is infact beneficial in some regards, but when within a tolerable level. If side effects become noticed the use of Tamoxifen Citrate may control the situation. Many find taking 60mg on the first day, 40mg for a week, then 20mg until PCT begins, proves fruitful.
A great protocol for PCT use of Nolvaxyl is to take 100mg on day one, 60mg for the next 10 days, then 40mg for a week, ending with 20mg for the last week.
While the use of Nolvaxyl may be beneficial in the blocking on estrogenic effects, a stronger option may be needed, and for this we would look to opt for an anti-aromatase. Whilst an oestrogen agonist/antagonist such as tamoxifen citrate only blocks oestrogens effects, an anti-aromatase will work by slowing or halting the production of oestrogen in the first place. This may be of a more beneficial option for those using heavier cycles, or those prone to related side effects, as this methods is a lot more effective. The combination of both type of drugs may be fruitful by ceasing estrogenic effects via both mechanisms.